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It converts vitamin B9 (folate) into methyl-folate, which is essential for a process called methylation

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K + balance and water homeostasis are maintained through Kir4.1 and AQP4 channels, respectively, which are localized at the perivascular endfeet 108,109

Overall, these findings indicate that reductions in GPx3 abundance trends with disease severity with stage 1 having the highest mean levels of GPx3 (1.99 g/ml 0.73 g/ml) and the highest K1/U1 ratio (0.86), followed by the stage 2 with a mean of 1.2 g/ml 0.54 g/ml and average K2/U2 ratio of 0.67, with the most severe form of konzo, stage 3, displaying the largest reduction in average protein abundance (mean: 1.15 g/ml 0.58 g/ml) and the lowest K3/U3 ratio of 0.59 (Supplementary Data 1)

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